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Patents Listed in the FDA Orange Book Drug Database of Januvia with information and expiry/expiration dates. Januvia is sometimes used in combination with other diabetes medications, but is not for treating type 1 diabetes. This may change due to patent challenges or generic licensing. Januvia is thought to work by slowing the. Common Januvia side effects may include: low blood sugar; headache; or. When used in addition to diet and exercise, Januvia has been shown to improve blood sugar control (your A1C). Many people using Januvia do not have serious side effects. Side effects that may occur with Januvia include: headache, joint or muscle pain, nausea, stomach pain, diarrhea, or constipation symptoms of heart failure shortness of breath (even while lying down), swelling in your legs or feet, rapid weight gain. Januvia isn’t available as a generic drug 11-09-2018 Print. The Januvia patent related to the basic compound is set to expire in July 2022. 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